Publications

Nawarathnage S, Tseng YJ, Soleimani S, Smith T, Pedroza Romo MJ, Abiodun WO, Egbert CM, Madhusanka
D, Bunn D, Woods B, Tsubaki E, Stewart C, Brown S, Doukov T, Andersen JL, Moody JD. Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain. In Press at Structure. Preprint posted on BioRXIV: bioRxiv 2023.06.14.544429;

Gajjar PL, Pedroza Romo MJ, Litchfield CM, Callahan M, Redd N, Nawarathnage S, Soleimani S, Averett J,
Wilson E, Lewis A, Stewart C, Tseng YJ, Doukov T, Lebedev A, Moody JD. Decreasing the flexibility of the TELSAM-target protein linker and omitting the cleavable fusion tag improves crystal order and diffraction limits. In Press at Acta Crystallographica Section D. Preprint posted on BioRXIV: bioRxiv 2023.05.12.540586;

Moody JD, Hill S, Lundahl M, Saxton AJ, Galambas, AK, Broderick WE, Lawrence CM, Broderick JB. A pyruvate formate-lyase activating enzyme variant computationally engineered for crystallization: Structural insights into S adenosylmethionine binding and reductive cleavage. Journal of Biological Chemistry. 2023, 104791.

Lin HL, James I, Hyer CD, Haderlie CT, Zackrison MJ, Bateman TM, Berg M, Park JS, Daley SA, Zuniga Pina NR, Tseng YJ, Moody JD, Price JC. Quantifying In Situ Structural Stabilities of Human Blood Plasma Proteins Using a Novel Iodination Protein Stability Assay. Journal of Proteome Research. 2022 Dec 2;21(12):2920-2935.

Nawarathnage S, Soleimani S, Mathis MH, Bezzant BD, Ramírez DT, Gajjar P, Bunn DR, Stewart C, Smith T,
Pedroza Romo MJ, Brown S, Doukov T, Moody JD. Crystals of TELSAM-target protein fusions that exhibit minimal crystal contacts and lack direct inter-TELSAM contacts. Open Biology. 2022 Mar;12(3):210271.

Walls WG, Moody JD, McDaniel EC, Villanueva M, Shepard EM, Broderick WE, Broderick JB. The B12-independent glycerol dehydratase activating enzyme from Clostridium butyricum cleaves SAM to produce 5´-deoxyadenosine and not 5´-deoxy-5´-(methylthio)adenosine. Journal of Inorganic Biochemistry. 2022 Feb;227:111662.

Chan TY, Egbert CM, Maxson JE, Siddiqui A, Larsen LJ, Kohler K, Balasooriya ER, Pennington KL, Tsang TM, Frey M, Soderblom EJ, Geng H, Müschen M, Forostyan TV, Free S, Mercenne G, Banks CJ, Valdoz J, Whatcott CJ, Foulks JM, Bearss DJ, O'Hare T, Huang DCS, Christensen KA, Moody J, Warner SL, Tyner JW, Andersen JL. TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth. Nature Communications. 2021 Sep 9;12(1):5337.

Coates TL, Young N, Jarrett AJ, Morris CJ, Moody JD, Della Corte D, Current computational methods for enzyme design. Modern Physics Letters B. 2021;33(0):2150155-1–30.

Ludlam WG, Aoba T, Cuéllar J, Bueno-Carrasco MT, Makaju A, Moody JD, Franklin S, Valpuesta JM, Willardson BM. Molecular architecture of the Bardet–Biedl syndrome protein 2-7-9 subcomplex. Journal of Biological Chemistry. 2019 Nov 1;294(44):16385-99.

Moody JD, Levy S, Mathieu J, Xing Y, Kim W, Dong C, Tempel W, Robitalle A, Dang LT, Ferreccio A, Detraux D, Sidhu S, Zhu L, Carter L, Xu C Wang Y, Valensisi C, Hawkins D, Min J, Moon R, Orkin SH, Baker D, Ruohola-Baker H. First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor. Proc. Nat. Acad. Sci. USA. 2017 Sep 19;114(38):10125-10130.

Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ, Garcia KC. Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signaling. Nature. 2017 May 11;545(7653):234-237.

Swiderski K, Shaffer SA, Gallis B, Odom GL, Arnett AL, Scott Edgar J, Baum DM, Chee A, Naim T, Gregorevic P, Murphy KT, Moody J, Goodlett DR, Lynch GS, Chamberlain JS. Phosphorylation within the cysteine-rich region of dystrophin enhances its association with β-dystroglycan and identifies a potential novel therapeutic target for skeletal muscle wasting. Hum Mol Genet. 2014 Jul 31. pii: ddu388.

Grange J, Moody JD, Ascione MP, Hansen MD. Zyxin-VASP interactions alter actin regulatory activity in zyxin-VASP complexes. Cell and Molecular Biology Lett. 2013 Mar;18(1):1-10.

Wang L, Althoff EA, Bolduc J, Jiang L, Moody J, Lassila JK, Giger L, Hilvert D, Stoddard B, Baker D. Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design. Journal of Molecular Biology. 2012 Jan 20;415(3):615-25.

Moody JD, Grange J, Ascione MP, Boothe D, Bushnell E, Hansen MD. A zyxin head-tail interaction regulates zyxin-VASP complex formation. Biochemical and Biophysical Research Communications. 2009 Jan 16; 378(3):625-628.