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Ultrasensitive Biochemical Analysis

The Kelly lab focuses on developing methods, instrumentation and applications for in-depth bioanalyses of trace samples. Single-cell and high-resolution spatial proteomics are of particular interest. Current research efforts include:

  • Simplifying and increasing efficiency of sample preparation for trace samples
  • Miniaturizing separations for ultrasensitive measurements
  • Developing LC instrumentation with no compromise between robustness, sensitivity and measurement throughput
  • Alternative MS data acquisition strategies to get more information from trace samples
  • Applications in cancer and neurodegenerative diseases