The Kelly lab focuses on developing methods, instrumentation and applications for in-depth bioanalyses of trace samples. Single-cell and high-resolution spatial proteomics are of particular interest. Current research efforts include:

• Simplifying and increasing efficiency of sample preparation for trace samples
• Miniaturizing separations for ultrasensitive measurements
• Developing LC instrumentation with no compromise between robustness, sensitivity and measurement throughput
• Alternative MS data acquisition strategies to get more information from trace samples
• Applications in cancer and neurodegenerative diseases